Blood Relatives: Artificial Oxygen Carriers between Promise and Concern
نویسندگان
چکیده
منابع مشابه
Blood substitutes Artificial oxygen carriers: perfluorocarbon emulsions
Perfluorocarbon emulsions are being clinically evaluated as artificial oxygen carriers to reduce allogeneic blood transfusions or to improve tissue oxygenation. Perfluorocarbon emulsions are efficacious in animal experiments, and in humans they are well tolerated and at least as successful to reverse physiologic transfusion triggers than autologous blood. Perfluorocarbon emulsions may be used i...
متن کاملArtificial oxygen carriers: a new future?
Despite the fact that allogeneic red blood cell (RBC) transfusions can be life-saving in exsanguinating trauma patients, many adverse events impacting patient outcome have documented [1]. Therefore, artificial oxygen carriers were initially been developed as “blood substitutes” in the 1980s and 1990s. Artificial oxygen carriers can be grouped into hemoglobin-based oxygen carriers (HBOCs) and pe...
متن کاملArtificial oxygen carriers: a current review.
Artificial oxygen carriers are not blood substitutes. They serve to carry oxygen to tissues and are either hemoglobin based or perfluorocarbon based. Driving the development of artificial oxygen carriers are concerns involving both the safety and quantity of the blood supply. No artificial oxygen carriers are currently approved for clinical use in the United States. Hemopure has been approved f...
متن کاملArtificial oxygen carriers as red blood cell substitutes: a selected review and current status.
Two distinct approaches are being explored in red blood cell substitute (RCS) development: hemoglobin-based oxygen carriers (HBOCs) and perfluorocarbon-based oxygen carriers (PFBOCs). HBOCs are based on intra- and/or intermolecularly "engineered" human or animal hemoglobins (Hbs), optimized for O2 delivery and longer intravascular circulation. Some are currently being evaluated in Phase II/III ...
متن کاملThe Design of Blood Substitutes: Oxygen Carriers
Hospitals throughout the world currently rely solely on allogeneic blood (also referred to as donor blood) for transfusions. Estimates put worldwide blood demand somewhere between 75 and 90 million units per year 1. Canada’s requirements account for 800 000 units per year and the United States for 12 million2,3. One unit of blood represents approximately a volume of 450 mL. Based on current req...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2007
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2007.10.003